可溶性人基质裂解素2与高敏心肌肌钙蛋白对急诊胸痛患者短期预后影响被引量：4

下载PDF

导出

摘要目的探讨可溶性人基质裂解素2(sST2)与高敏心肌肌钙蛋白(hs-cTnI)对急诊胸痛患者的短期预后影响。方法选取南通大学附属东台人民医院急诊科自2016年1月至2018年1月收治的120例急性胸痛患者为研究对象。其中,急性冠脉综合征(ACS)组46例[ST段抬高型心肌梗死(STEMI)25例,非ST段抬高型心肌梗死(NSTEMI)21例],非ACS组74例。检测患者急性胸痛24 h内血浆sST2、hs-cTnI水平。采用单因素及多因素Logistic回归分析血清sST2、hs-cTnI水平与患者30 d随访期内病死率的关系。结果入院24 h,ACS组患者血清sST2、hs-cTnI均明显高于非ACS组,两组间比较,差异均有统计学意义(P<0.05)。单因素分析结果显示,sST2、hs-cTnI、体质量指数(BMI)与心肌梗死溶栓试验(TIMI)评分对患者预后有影响。多因素Logistic回归分析结果显示,sST2、TIMI评分均为评估患者预后的独立影响因素(P<0.05)。结论与hs-cTnI比较,sST2评估急性胸痛患者短期预后的灵敏度更高,可单独作为早期评估心血管不良事件预后的指标。

作者许俊华林凤芹吴德龙梁春波

机构地区南通大学附属东台人民医院急诊科北部战区总医院干二科

出处《临床军医杂志》 CAS 2019年第5期534-535,共2页 Clinical Journal of Medical Officers

基金江苏省卫生计生委指导性科研课题(Z201624)

关键词胸痛急性冠脉综合征可溶性人基质裂解素2 高敏心肌肌钙蛋白预后

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献3

1刘洪军,杨猛,张开忠.NT-proBNP、CysC和PCT对急性冠脉综合征患者预后评估的应用价值[J].广西医科大学学报,2017,34(8):1145-1149. 被引量：14
2李永勤,范艳梅,薛嘉红,张春燕,张岩,栾春红.高敏C反应蛋白联合高敏心肌肌钙蛋白T对急性冠状动脉综合征患者预后的判断价值[J].中国医师进修杂志,2014,37(22):5-9. 被引量：5
3陈伟伟,高润霖,刘力生,朱曼璐,王文,王拥军,吴兆苏,李惠君,顾东风,杨跃进,郑哲,蒋立新,胡盛寿.《中国心血管病报告2017》概要[J].中国循环杂志,2018,33(1):1-8. 被引量：2097

二级参考文献29

1张坚,满青青,王春荣,李红,由悦,翟屹,李莹,赵文华.中国18岁及以上人群血脂水平及分布特征[J].中华预防医学杂志,2005,39(5):302-305. 被引量：112
2Sheikh AS,Yahya S,Sheikh NS,et al. C-reactive protein as a predictor of adverse outcome in patients with acute coronary syndrome[J]. Heart Views,2012,13( 1 ) :7-12.
3Jalal D, Chonchol M, Etgen T, et al. C-reactive protein as a predictor of cardiovascular events in elderly patients with chronic kidney disease [ J ]. J Nephrol, 2012,25 (5) : 719-725.
4Kouvelos GN, Milionis HJ,Amaoutoglou EM,et al. Postoperative levels of cardiac troponin versus CK-MB and high-sensitivity C-reactive protein for the prediction of 1-year cardiovascular outcome in patients undergoing vascular surgery [J]. Coron Artery Dis, 2011,22(6) :428-434.
5Taniguchi H, Momiyama Y, Ohmori R, et al. Associations of plasma C-reactive protein levels with the presence and extent of coronary stenosis in patients with stable coronary artery disease [J]. Atherosclerosis, 2005,178( 1 ) : 173-177.
6Chew DP,Bhatt DL,Robbins MA,et al. Incremental prognostic value of elevated baseline C-reactive protein among established markers of risk in percutaneous coronary intervention [J]. Circulation, 2001,104 (9) : 992-997.
7Poon PY,Szeto CC,Kwan BC,et al. Relationship between CRP polymorphism and cardiovascular events in Chinese peritoneal dialysis patients [ J ]. Clin J Am Soc Nephrol, 2012,7 (2) : 304-309.
8Shimada K, Fujita M,Tanaka A,et al. Elevated serum C-reactive protein levels predict cardiovascular events in the Japanese coronary artery disease (JCAD)study [J ]. Circ J, 2009,73 ( 1 ) : 78- 85.
9Eggers KM, Lagerqvist B, Venge P, et al. Persistent cardiac troponin I elevation in stabilized patients after an episode of acute coronary syndrome predicts long-term mortality [J ]. Circulation, 2007,116 (17) : 1907-1914.
10Hochholzer W, Reichlin T, Twerenbold R, et al. Incremental value of high-sensitivity cardiac troponin T for risk prediction in patients with suspected acute myocardial infarction [J]. Clin Chem, 2011,57(9) : 1318-1326.