孕期丙硫氧嘧啶摄取对新生儿甲状腺功能影响

Effect of prenatal intake of propyl sulfur on thyroid function in neonates

目的探讨孕期丙硫氧嘧啶摄取对新生儿甲状腺功能的影响。方法选取自2016年9月至2018年2月池州市人民医院收治的90例甲状腺功能亢进孕产妇为研究对象。根据患者意愿分为A组(n=29)和B组(n=61)。A组不进行药物治疗,B组接受丙硫氧嘧啶治疗,比较两组的妊娠结局及孕产妇、新生儿的甲状腺功能。结果治疗后,B组孕产妇血清总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平均显著优于A组,两组间比较,差异均有统计学意义(P<0.05)。B组早产率、剖宫产率及畸形率均显著低于A组,两组间比较,差异均有统计学意义(P<0.05)。B组新生儿血清TT3、TT4、FT3、FT4、TSH水平均显著优于A组,两组间比较,差异均有统计学意义(P<0.05)。结论丙硫氧嘧啶治疗妊娠期甲状腺功能亢进可有效改善母婴的甲状腺功能及妊娠结局。

Objective To investigate the effect of prenatal intake of propyl sulfur on thyroid function in neonates.Methods A retrospective study was performed on 90 cases of pregnant and lying-in women with hyperthyroidism who were admitted from September 2016 to February 2018.According to the aspiration,patients were divided into the Group A(n=29)and Group B(n=61).No drug treatment was performed in Group A,and propyl pyrimethamine was administered in Group B to compare the pregnancy outcomes of the two groups and the thyroid function of pregnant and pregnant women and newborns.Results After treatment,the serum total triiodothyrosine,total thyroxine,free triiodothyronine,free thyroxine,and thyroid stimulating hormone levels of pregnant and lying-in women in Group B were significantly higher than those in Group A,and the differences between the two groups were statistically significant(P<0.05).The premature delivery rate,cesarean section rate and deformity rate in Group B were significantly lower than those in Group A(P<0.05).The serum levels of total triiodothyrosine,total thyroxine,free triiodothyronine,free thyroxine,and thyroid stimulating hormone in Group B were significantly higher than those in Group A(P<0.05).Conclusion Propyrrolidine in the treatment of hyperthyroidism during pregnancy can effectively improve maternal and infant thyroid function and pregnancy outcome.