急性颅内压增高与呼吸、血压、瞳孔及脑电图改变的实验研究

Acutely increased intracranial pressure and sequential alteration in respiration, blood pressure, pupils and electroencephalogram: an experimental study

呼吸、脉搏、血压、瞳孔及脑电图是神经外科临床中的重要观察指标、当急性颅内压增高时,上述指标往往发生改变。对此,临床医生已较熟悉,但对于造成上述改变的颅内压力高度和其动态变化过程了解尚较少。本文拟通过急性颅内压增高的实验研究,对此问题做一初步探讨。

Acutely increased intracranial pressure (ICP)and sequential alteration in vital sign, pupils and electroencephalogram (EEG) were observed in cats treated by inflation of the extradural balloon.The baseline intracranial pressure (ICP) was 2-12 mmHg. When it rises to 38.89+2.0 mmHg, declining amplitude and frequency of EEG appeared; to 41.1±1.95 mmHg, the respiratory rate decreased; to 49.5±2.64 mmHg, the ipsilateral pupil enlarged; to 66.19±2.56 mmHg, both pupils dilated; to 71.22±3.21 mmHg, the blood pressure elevated; to 78.50±5.69 mmHg, the EEG curve became flat; and to 83.25±5.49 mmHg, the apnea occurred.In the discussion, author put forward some points for paying attention in making experimental model of increased ICP, analyse the connection between alteration of ICP and Cushing's response and agree to take ICP>40 mmHG as a severe intracranial hypertention.