内因性葡萄膜炎患者血清中抗色素膜抗体意义的初步探讨

A preliminary study on aanti-uvea autoantibody in patiants with endogenous uveitis

临床上由于内因性葡萄膜炎具有慢性病程、反复发作、对糖皮质激素治疗敏感三大特点而普遍认为是与免疫有关的疾病。60年代已有许多学者通过免疫扩散和补体固定技术证明葡萄膜炎患者体内有抗色素膜抗体。70年代以来陆续有关于患者体内细胞免疫功能紊乱的研究报道。

It has been established that endogenous uveitisisretated to immune reactions and autoimmune phenomena may be one of the causes that initiate the disease. The pathogenesis, however, is obscure.With the indirect immunofluorescent meshod, the anti-urea autoantibodies in the sera from 21 patients and 15 controls were examined. The results showed that positive rate is 71% in patients and 13% in controls. The autoantibodies appeared in sclera, choroid, and iris, mainly, in the wall of vessels. This indicaes that the presence of autoantibodies is probably an etiologic factor for the development of endogeneous uveitis.