维胺酯四环素联合治疗51例痤疮疗效观察

Combined treatment of 51 cases with retinamidoester and tetracycline

痤疮是男女青年常见、多发皮肤病。确实影响青年人的身心健康。随着对痤疮病因及发病机理的了解,在治疗上有了显著的进展。作者采用维甲酸类衍生物维胺酯(retinami-doester)与四环素联合治疗51例重症痤疮,取得了较好的疗效,现小结汇报如下:一、一般资料:51例,男性33例,女性18例。平均年龄21.7岁(14～37岁),平均病期4.3年(1～16年)。寻常性痤疮16例,结节囊肿性痤疮16例,聚合性痤疮10例。

The author used retinoid derivative,retinamidoester combined with tetracycline for 51 cases of severe acne.Good response was obtained.Cases in this series comprised 16 acne vulgaris:16 nod- ular-cyst acne,10 acne conglobata,6 pustular acne and one cases of ache keloid,rosacea and peri- folliculitis capitis abscedens et suffodiens each.Retinamidoester was given 1—1.5mg/kg/d or 25 mg Tid,while tetracycline given 10—15mg/kg/d or 250 mg Tid.Each course was carried out for at least 8 weeks or more.Clinical cure was noted in 20 cases(39.2%),markedly improved in 19 cases(37.3%),improved in 11 cases(21.6%),not improved in only one case(1.9%).Rate of markedly improved cases was 76.5% and overall rate of improvement 98.1%.Side effects was found in 8 cases,rate of side effects was 15.6%.The treatment response,side effects and mech- anism of retinamidoester combining with tetracycline were discussed.