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以T淋巴母细胞淋巴瘤为首发表现的慢性髓系白血病1例报道

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摘要 慢性髓系白血病(chronic myeloid leukemia,CML)是一种发生在多能造血干细胞的恶性骨髓增殖性肿瘤,主要涉及髓系。外周血粒细胞显著增多且不成熟,在受累的细胞系中,存在Ph染色体和(或)BCR/ABL1融合基因。该基因由9号染色体长臂上C-ABL原癌基因易位至22号染色体长臂的断裂点簇集区形成,其编码的蛋白具有酪氨酸酶活性,导致CML的发生。
出处 《解放军医学院学报》 CAS 2019年第1期88-90,94,共4页 Academic Journal of Chinese PLA Medical School
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