血清PCT联合CRP检测在儿童过敏性紫癜中的临床意义

Clinical value of combined detection of serum PCT and CRP in children with allergic purpura

目的探讨血清降钙素原(PCT)和C反应蛋白(CRP)联合检测在儿童过敏性紫癜中的临床意义,为临床寻找诱因及治疗提供依据。方法选取该院2017年6月至2018年6月住院的过敏性紫癜患儿50例(无肾脏损害组30例、有肾脏损害组20例),门诊健康体检儿童20例(对照组),采用免疫化学发光法和免疫散射比浊法同时检测血清PCT和CRP水平。结果过敏性紫癜患儿血清PCT和CRP水平明显高于对照组儿童,差异有统计学意义(P<0.05);有肾脏损害组的PCT和CRP均高于无肾脏损害组和对照组,差异有统计学意义(P<0.05);有肾脏损害组的PCT、CRP阳性率显著高于对照组,差异均有统计学意义(P<0.05)。结论过敏性紫癜合并肾脏损害患儿血清PCT和CRP均升高,联合检测可以提高HSP合并肾脏损害的检出率。

Objective To explore clinical value of combined detection of procalcitonin(PCT)and C-reactive protein(CRP)in children with allergic purpura.Methods A total of 50children with allergic purpura were selected,in which,there were 30cases without kidney damage and 20cases with kidney damage.In addition,20 healthy cases were selected as control group.Serum PCT and CRP levels were detected by immunofluorescence quantitative method and immunoturbidimetry respectively.Results Levels of PCT and PCR were significantly higher than that of control group(P<0.05).Serum PCT and CRP levels of children with kidney damage were significantly higher than that of control group(P<0.05).Positive rates of PCT and CRP children with kidney damage were significantly higher than that of control group(P<0.05).Conclusion Levels of PCT and CRP has increased in children with allergic purpura.Combined detection of PCT and CRP in children with allergic purpura could be used as a clinical indicator for monitoring renal impairment.