老年恶性肿瘤患者D-二聚体及血小板CD62_p检测的临床意义

Clinical significance of detecting Ddimer and CD62_p of the platelet in the olderly patients with malignant tumor

目的探讨老年恶性肿瘤患者手术前后血浆D-二聚体及血小板CD62p的变化规律,为术后抗凝治疗,预防继发血栓病提供客观依据。方法应用流式细胞术和胶体金方法分别检测39例老年恶性肿瘤患者、32例非老年恶性肿瘤患者、55例老年健康对照组的血小板CD62p及血浆D-二聚体。结果两组恶性肿瘤患者血小板CD62p及血浆D-二聚体含量均明显高于正常老年对照组(P【0.001),且术后显著高于术前(P【0.001)。术后老年恶性肿瘤患者血小板CD62p及血浆D-二聚体含量明显高于非老年恶性肿瘤患者(P【0.001),术前两组恶性肿瘤患者无明显差异(P】0.05)。结论手术对恶性肿瘤患者血小板有明显活化作用,并能促进高凝状态的发生,老年患者更为显著,故应重视手术后的防凝措施,以预防血栓病的发生。

Objective To investigate disciplinarians of the changes of Ddimer in plasma and CD62_p(GMP140)of the platelet between before and after surgery in the patients with malignant tumor. Methods The levels of Ddimer and CD62_p were detected using flow cytometry and an immunometric folwthrough principle in 76 samples of the olderly patients with malignant tumor,51 samples of the nonolderly patients with malignant tumor and 55 samples of the olderly normal donator,respectively. Results The levels of Ddimer and CD62_p in the two groups with malignant tumor after surgery were remarkably higher than before(P<0.001)and no matter before and after surgery in the patients with malignant tumor were considerably higher than the donator.After surgery the ratio of Ddimer and CD62_p in the olderly patients with malignant tumor were significantly higher than in the nonolderly patients(P<0.001),but there were no significant difference between the two groups with malignant tumor(P<0.005). Conclusion Surgery aroused an activating of the platelet from the patients with malignant tumor and promoted coagulation,furthermore in the olderly patients.