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检测血小板糖蛋白分子对高血压、脑梗死的临床价值

The detection and significance of platelet glycoprotein in patients with hypertension and cerebral infarction
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摘要 目的通过测定高血压、脑梗死患者血小板糖蛋白(CD62P,CD63,PAC-1)和纤维蛋白原(FIB)指标,旨在为临床治疗高血压、脑梗死提供有用的参考指标。方法采用流式细胞术(FCM),对85例高血压脑梗死患者,42例正常血压脑梗死患者、35例原发性高血压患者血小板糖蛋白CD62P,CD63,PAC-1进行检测,用血凝仪测定FIB。结果高血压脑梗死组、正常血压脑梗死组与原发性高血压组血小板糖蛋白CD62P、CD63、PAC-1及FIB均显著高于正常对照组(均P【0.001),且高血压脑梗死组、正常血压脑梗死组血小板糖蛋白CD62P、CD63、PAC-1及FIB均明显高于高血压组(均P【0.001)。高血压脑梗死组与正常血压脑梗死组血小板糖蛋白CD62P、CD63、PAC-1及FIB均无明显差异。高血压脑梗死组与正常血压脑梗死组血小板糖蛋白CD62P、CD63、PAC-1的平均荧光强度均显著高于正常对照组(均P【0.001),原发性高血压组PAC-1的平均荧光强度均显著高于正常组(P【0.05);高血压脑梗死组、正常血压脑梗死组的血小板糖蛋白CD62P、CD63、PAC-1的平均荧光强度均显著高于高血压组(分别P【0.001,P【0.001,P【0.05,P【0.001,P【0.001,P【0.05)。高血压脑梗死组与正常血压脑梗死组的血小板糖蛋白CD62P、CD63、PAC-1的平均荧光强度均无明显差异。结论FCM检测血小板糖蛋白,结果准确,对高血压患者的病情分析和脑梗死的预防以及早期诊断和治疗具有重要的意义。 Objective To supply a reference measure,To examine platelet glycoproteins(CD62,CD63,PAC-1)and FIB in patients with hypertension and cerebral infarction.Methods The expression of platelet glycoproteins(CD62p,CD63,PAC-1)were measured by flow cytometry(FCM)in 85 cerebral infarction patients with high blood pressure、42 cerebral infarction with normal blood pressure and 35 hypertension patients.The FIB were also measured by Acl-Advance instruments.Results The expression of CD62p,CD63,PAC-1 and FIB in the cerebral infarction patients with high blood pressure、the cerebral infarction with normal blood pressure and the hypertension patients were significantly higher than those in controls.The expression of platelet glycoprotein CD62p,CD63,PAC-1 and FIB in the cerebral infarction patients with high blood pressure and the cerebral infarction patients with normal blood pressure were significantly higher than those in hypertension patients.The expression of platelet glycoprotein CD62p,CD63,PAC-1 and FIB made no difference in both cerebraloinfarction patients with high blood pressure and cerebral infarction patients with normal blood pressure.The mean intensity of fluronescence of platelet glycoprotein(CD62p,CD63,PAC-1)in the cerebral infarction patients with high blood pressure and the cerebral infarction patients with normal blood pressure were significantly higher than those in controls.The mean intensity of fluronescence of PAC-1 in the hypertension patients were significantly higher than those in controls.The mean intensity of fluronescence of platelet glycoprotein CD62p,CD63,PAC-1 in both cerebral infarction patients with high blood pressure and the cerebral infarction patients with normal blood pressure were significantly higher than those in the hypertension patients.The mean intensity of fluronescence of platelet glycoprotein CD62p,CD63,PAC-1 made no difference in both cerebral infarction with high blood pressure and the cerebral infarction patients with normal blood pressure.Conclusion The measurement of platelet glycoprotein has important clinical reference value in patients condition development and the early diagnosis of cerebral infarction.
出处 《浙江检验医学》 2007年第4期13-15,共3页 Zhejiang Journal of Laboratory Medicine
关键词 脑梗死 高血压 血小板糖蛋白 流式细胞术 Cerebral infarction Hypertension Platelet glycoprotein Flow cytometry
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