儿童1型糖尿病患者柯萨奇病毒感染的调查

Study on coxsackivirus infection in childrem with type 1 diabetes mellitus

目的探讨柯萨奇病毒感染在儿童1型糖尿病(T1DM)中的作用。方法采用ELISA方法检测108例T1DM患者(其中48例新发T1DM和60例缓解患者)和110例正常对照者柯萨奇病毒的IgM和IgG血清水平。结果108例患儿中柯萨奇病毒的IgM抗体阳性率为39.82%,而正常对照组为10%,差异有显著性意义(P【0.001)。柯萨奇病毒的IgM抗体的阳性率在两组间则没有显著差异(P】0.05)。在48例新发T1DM患儿中柯奇病毒IgM抗体的检出率为70.8%(34/48),而60例缓解T1DM患儿为15%(9/60),两者显著差异(P【0.001)。结论柯萨奇病毒在儿童1型糖尿病患者的感染率较高,其在1型糖尿病患者发病中的作用值得进一步研究。

Objective To investigate the relationship between type and 1 diabetes melitus(T1DM)and coxsackivirus(CV)infection.Methods In the present study,we measured the CV specific IgM IgG antibodies in seum from 108 T1DM and 110 controls by enzmme linked immunosorbent assay(ELISA).Results Among 108 of T1DM,39.82% of them had positive CV specific IgM antibody,while the positive rate in 110 controls was 10%.In the meanwhile,the CV specific IgG antibody was found positive in 82% of T1DM and in 79% of controls,respectively.Conclusion The results of this study suggest that there may be a significant correlation between type 1 diabetes meliitus and CV infection.