糖尿病患者血清肝细胞生长因子对诊治糖尿病肾病的临床价值

Study of hepatocyte growth factor in serum of diabetic nephropathy patients

目的探讨血清肝细胞生长因子(HGF)在2型DM不同肾损害期中的变化及其临床意义。方法收集2型DM患者85例,其中尿白蛋白正常组28例,尿白蛋白微量组30例,尿白蛋白明显增高组27例;糖耐量异常患者29例,采用ELISA法检测血清HGF水平。同时检测尿微量白蛋白。结果糖耐量异常组和尿白蛋白正常组HGF浓度明显高于对照组(P【0.05);尿白蛋白微量组及尿白蛋白明显增高组HGF浓度低于对照组(P【0.05);且尿白蛋白明显增高组又显著低于尿白蛋白微量组(P【0.05)。结论2型DM患者不同肾损害期HGF浓度差别有统计学意义,检测血HGF水平可为糖尿病肾病的诊断和治疗监测提供可靠依据。

Objective To study the changes and clinical significance of serum hepatocyte growth factor(HGF)in different period of kidney damage in type 2 diabetic.Methods 85 cases of type 2 diabetic patients(in which,normal albuminuria group:28 cases,a little more than normal albuminuria group:30 patients,large more than normal albuminuria group:27 cases),patients with glucose resistent abnormal:29 cases were respectively collected,and serum HGF levels were tested with ELISA,and 24 hours patients urine collected at the same day was used for nephelometry to detect urinary micro-albumin.Results HGF concentrations in glucose resistence abnormal group and normal albuminuria group are significantly higher than that in control group(P<0.05);HGF concentrations in a little more than normal albuminuria group and large more than normal albuminuria group are significantly lower than that in control group(P<0.05),and HGF concentrations in large more than normal albuminuria group is significantly lower than that in micro-albuminuria group(P<0.05).Conclusion There is statistical significance of HGF concentrations in different kidney damage stages of type 2 diabetic,and serum levels of HGF can provide a dependable theoretical basis for diagnosis and treatment-monitoring of diabetic nephropathy.