r-谷氨酰转移酶和缺糖转铁蛋白百分比对重度饮酒的诊断价值

Evaluating the clinical value on gammaglutamyltransferase and carbohydrate deficient transferrin to diagnose heavy alcohol consumption

目的探讨谷氨酰转移酶(GGT)、缺糖基转铁蛋白百分比(%CDT)与酒精摄入量的相关性和对早期诊断酒精相关性疾病的临床意义。方法将198例研究对象分成轻度、中度、重度饮酒和不饮酒四组,分别检测GGT、%CDT。结果重度饮酒组GGT和%CDT明显高于其余各组(均P【0.05),且随着酒精摄入量的增加而升高;GGT和%CDT对诊断重度饮酒的敏感性和特异性分别为47%、82%和10%、97%,联合GGT和%CDT其敏感性和特异性为41%和96%,比单独应用GGT特异性有所提高,比单独应用%CDT敏感性有所提高。结论 GGT和%CDT对重度饮酒具有较高的诊断价值。

Objective The aim of the study is to explore the relationship between alcohol consumption and gammaglutamyltransferase,carbohydrate deficient transferrin and evaluate its clinical value to diagnose heavy alcohol consumption and early alcohol diease.Methods 198 samples were grouped to no-drinkers,mild drinkerssmoderate drinkers and heavy drinkers.Serum GGT、%CDT were examined.Results There were significant higher in GGT and%CDT levels with heavy drinkers than those with other groups(P < 0.05),and there were progressive increase in GGT and%CDT levels with increased alcohol intake;GGT and%CDT were to diagnose heavy drink,the sensitivity and the specificity respectively is 47%,82%and 10%,97%.combine GGT and%CDT it’s sensitivity and the specificity is 41%and 96%,it is higher in sensitivity than using GGT alone,and it is higher in specificity than using%CDT alone.Conclusion Heavy alcohol consumption results in GGT and%CDT increasing,GGT and%CDT had higher value to diagnose heavy alcohol consumption.