5-氟尿嘧啶治疗急性胰腺炎的机制探讨

Mechanism of 5-fluorouracil in the treatment of acute pancreatitis

目的 探讨 5 -氟尿嘧啶 (5 FU )治疗急性胰腺炎 (AP )的机制。方法 将SD大鼠分为 3组 :急性胰腺炎组 (n =12 ) ,5 FU治疗组 (n =10 ) ,对照组 (n =10 )。治疗组在模型制作成功后立即经外周静脉注射 5 FU (1mg 10 0g)。术后 12h收集血浆 ,检测一氧化氮 (NO )及白细胞介素 -6(IL 6) ,并观察动物的生存率及生存时间。结果 5 FU治疗组大鼠 12h生存率较AP组提高 ,平均生存时间较对照组明显延长 ,腹水量明显减少 ,血循环中炎症介质水平明显降低。结论 炎症介质IL 6,NO在AP发病过程中有重要作用 ;5 FU通过阻断IL 6和NO的水平而发挥治疗AP的作用。

Objective To study the mechanism of 5 fluorouracil(5 FU) in the treatment of severe acute pancreatitis(SAP). Methods SD rats were randomly divided into three groups:acute pancreatitis group (AP group,n=12), 5 FU treatment group( 5 FU group,n=10),and control group (n=10). In 5 FU group,5 FU(1mg/100g) were injected immediately after AP was induced.12h after the AP was induced, blood samples were taken to determine nitric oxide(NO) and interleukin 6(IL 6). Results Compared with AP group,in 5 FU group, the survival rate increased,mean survival time prolonged,ascites volume decreased significantly,and the inflammatory mediators subsided. Conclusions NO and IL 6 may play an important role in the pathogenises of acute pancreatitis. The treatment effect of 5 FU for AP may through inhibit the inflammatory mediators.