胰腺癌的血管生成及临床意义

Clinical significance of angiogenesis in pancreatic carcinoma

目的 探讨人胰腺癌的微血管数量与肿瘤生物学特性的关系。方法 用免疫组织化学染色标记微血管内皮细胞 ,回顾性定量研究 5 5例人胰腺癌组织中微血管密度 (MVD ) ,并与临床病理学资料和随访资料作对比分析。结果 胰腺癌组织中平均微血管数量为 5 4.8± 18.6,癌旁组织中为11.2± 4.8,MVD与肿瘤细胞的分化程度、TNM分期、淋巴结转移有关 ,低血管组比高血管组术后生存时间明显延长。结论 胰腺癌的血管生成能反映肿瘤的恶性程度 ,MVD可作为胰腺癌分化、浸润、转移与预后分析的指标。

Objective To evaluate the relationship between angiogenesis and biological character of pancreatic carcinoma (PC). Methods Microvessel density (MVD) in 55 cases of PC were examined by use of immunohistochemical staining,and compared with the pathological features of PC. Results Mean MVD of PC was 54.8±18.6. MVD was positively correlated with tumor cell differentiation (P<0.05), TNM stages (P<0.05), and lymph node metastasis (P<0.01). Follow-up data suggested that postoperative survival time was significantly shorter in PC patients with high MVD than that in patients with low MVD .Conclusions Angiogenesis is highly related to the malignant degree of PC. MVD is one of the predictors for the biological behavior of PC.