立体定向放射加常规外照射治疗低分级脑胶质瘤

Stereotactic Radiotherapy plus Conventional Irradiation for Cerebral Low-grade Glioma

目的 :分析立体定向放射治疗加外照射治疗低分级胶质瘤的疗效 ,探讨影响其预后的因素。方法 :用立体定向放射治疗加常规外照射的方法治疗低分级胶质瘤31例。健康指数(KPS)平均71分。肿瘤体积按定位影像所见的肿瘤边缘描绘平均37.27cm3。立体定向放射治疗针对手术后残存的大块肿瘤 (GTV)追加剂量 ,每次5～7Gy,共计5～7次 ,常规外照射主要针对亚临床病变 ,一般剂量为40～56Gy,肿瘤总治疗剂量平均92.65Gy。结果 :本组病例的1、3、5年累积生存率分别为100 %、87.18 %和77.49 %。结论 :外照射加立体定向放射治疗是一种低分级胶质瘤的有效治疗方法 ,患者年龄和肿瘤部位是影响患者生存的主要因素。

Objective:To study the effect of stereotactic radiotherapy(SRT)plus conventional radiotherapy(CRT)on cerebral low-grade glioma.Methods:Thirty-one patients with low-grade glioma were treated with SRT plus CRT.The mean of Karnofsky score(KPS)was71.According to localization images,the mean of target volume was37.27cm 3 .The target of SRT was the gross tumor volume(GTV),and the dose of SRT was5～7Gy per fraction,total5～7fractions.The target of CRT was preclinical disease,and the dose of CRT was40～56Gy.Results:The cumulative survival rates at the lst,3ed and5th year were100%,87.18%and77.49%respectively.Conclusion:The age of the patients and the localization of the tumor were the primary factors to affect the prognosis.The method of SRT plus CRT was effective for cerebral low-grade glioma,but the manner of dose and fraction in clinical setting requires further investigation.