增龄对2型糖尿病患者的临床生化指标及慢性并发症的影响

Influence of Age on Clinical Biochemical Datum and Chronic Complications in Type 2 Diabetic Patients

目的 :观察年龄因素对2型糖尿病患者的临床生化指标及慢性并发症的影响。方法 :对90例不同年龄组的2型糖尿病患者进行血糖、血脂、血胰岛素及尿微量白蛋白水平进行测定 ,并观察不同年龄组中出现糖尿病慢性并发症的情况。结果 :≥70岁组与60～岁组及45～岁组相比 ,血糖、血胰岛素(空腹、餐后)、血甘油三酯及24h尿微量白蛋白均有显著性差异(P<0.01) ,而血胆固醇差异无显著性。其出现大、微血管慢性并发症的次数明显增多。结论 :随着年龄的增加 ,2型糖尿病患者的胰岛素水平下降 ,血糖、血脂及24h尿微量白蛋白升高 。

Objective:To investigate the influence of age on clinical biochemical datum and chronic compliˉcations in type2diabetic patients.Methods:The levels of blood glucose,lipid,insulin and24h urine microalbuˉmin(UMA)of90type2diabetic patients grouped by age were measured,and their chronic complications were observed.Results:There were significant differences in both fasting and postprandial blood glucose and insulin,triglyceride and24h UMA between≥70y group and60y or45y group(P<0.01),but there was not a significant difference in levels of cholesterol among the groups.Conclusion:with the age increasing the level of insulin deˉcreased,but the levels of blood glucose,lipid,insulin and24h UMA and the incidence of various chronic comˉplications increased obviously.