乙醇对兔心脏活动与氧自由基的影响

The effect of ethanol on heart's activity and oxygen free radicals of the rabbit

目的 :探讨不同量的乙醇对心脏活动和血浆中超氧化物歧化酶 (SOD)活力和丙二醛 (MDA)含量的影响。方法 :分别按家兔每 kg体质量累加 0 .2 ,0 .5 ,1.0 ,1.5 ,2 .0 g的乙醇从静脉给予 ,然后分别测定在不同量的乙醇作用下在体左心室内压变化情况 ,同时测定当时血浆中 SOD活力和 MDA的含量 ,并比较分析它们之间的关系。结果 :随着乙醇量的增加 ,左心室内压下降明显 ,但在 0 .2～ 0 .5 g/ kg时无明显变化。达 1.0 g/ kg以上时才明显降低 (P<0 .0 5或 P<0 .0 1)。 SOD活力 0 .2～ 0 .5 g/ kg时增加 ,达 1.0 g/ kg以上时降低 ;MDA含量在 0 .2～ 0 .5 g/ kg时降低 ,超过 1.0 g/ kg以上时增加。结论 :乙醇量大对心脏有抑制作用 ,同时体内氧自由基产生增多。

AIM: To investigate the effect of ethanol on heart's activity, SOD's(superoxide dismutase) activity in blood plasma and the amount of MDA(malondialdehyde) by using different doses of ethanol. METHODS: The change of internal pressure of left ventricle in vivo , SOD's activity in blood plasma and the amount of MDA were measured by intravenously injecting the ethanol with accumulative doses of 0.2, 0.5, 1.0, 1.5, and 2.0 g per kg body weight. RESULTS: With the increasing dose of ethanol, the internal pressure of left ventricle obviously reduced. But it showed no distinct changes within 0.2~0.5 g/kg but showed an evident decrease above the dose of 1.0 g/kg ( P <0.05 or P <0.01). SOD activity increased within 0.2~0.5 g/kg and decreased above 1.0 g/kg. Oppositely, MDA amount decreased with in 0.2~0.5 g/kg and increased above 1.0 g/kg. CONCLUSION: The study indicated that body's reaction to ethanol was related with the dose. A finite dose of ethanol would benefit health while an exciting dose would inhibit heart's activity and the oxygen free radicals would increase.