针灸穴位注射对肝纤维化大鼠细胞外基质成分影响的研究

目的:从针灸、穴注对肝纤维化大鼠细胞外基质影响的角度探讨针灸、穴注抗肝纤维化的作用及机制。方法:用CCL4诱导大鼠肝纤维化模型,以秋水仙碱为对照,观察针灸、穴注对大鼠肝组织胶原成分、FN、LN的影响。结果:与模型组相比,针灸、穴注组大鼠肝组织胶原含量、FN、LN明显减少。结论:针灸、穴注防治肝纤维化作用机制与针灸、穴注减少胶原FN、LN等ECM沉积有关。

Objective: To study the effects and its mechannism of Acup uncture - moxibustion and acupoits - injection on anti-hepatofibrosis from the way o f ECM. Methods: Hepatofibrosis model was induced in rats by CCL4 and meanwhile t reated by Acupuncture-moxibustion and acupoits- injection with Colchicines as con trol, Collagen、FN、LN、 in liver tissue were observed. Results:Compared with model group, Collagen、FN、LN in liver tissue were lower. Conclusion: Acupuncture and ac upoits- injection have preventive and therapeutic effects on hepatofibrosis, and i ts mechanism is related to reducing the deposition of ECM such as Collagen、FN、 LN.