营养不良大鼠胸腺褪黑素受体改变及意义

CHANGES OF MELATONIN RECEPTOR IN RATS OF MALNUTRITION AND ITS SIGNIFICANCE

为探讨营养不良对胸腺褪黑素受体(MR)表达的影响 ,以低蛋白饮食制备营养不良大鼠模型 ,应用放射配体结合法检测大鼠胸腺MR ,观察营养不良母鼠及所生幼鼠胸腺及胸腺MR改变。结果发现 ,孕前和孕中营养不良大鼠所生幼鼠胸腺发育障碍 ,胸腺MR也明显低于对照组 ,给予充足蛋白饮食后 ,哺乳幼鼠胸腺发育及胸腺MR明显改善。提示营养不良可导致胸腺发育障碍 ,使MR受体蛋白合成减少 。

To investigate the role of malnutrition on expression of thymus melatonin receptor(MR), rats were fed with low protein diet to induce an experimental animal model of malnutrition. MR was detected by radioligand binding assay. In malnourished rats before pregnancy and those during pregnancy, the thymus development in their offsprings was retarded, and the expression of MR was lower than that of the controls. After fed with standard diet,the development of the thymus and the MR in the infant rats improved significantly. The results suggest that malnutrition can retard the development of thymus, so the production of MR in thymus is lowered, and this may affect the physiological role of melatonin.