静脉注射免疫球蛋白早期治疗ABO溶血病的临床研究

Research on the effect of intravenous immunoglobin for the early treatment of ABO hemolysis

①目的 探讨早期静注免疫球蛋白(IVIG)治疗ABO溶血病的疗效。②方法 取新生儿脐血作血清学检查以判断ABO溶血病。随机分观察组13例,对照组12例。观察组于生后24h内用IVIG 800mg/(kg·d)静滴1次;对照组不用IVIG。两组其余治疗方案相同。定时检测静脉血血红蛋白(Hb)、总胆红素(TBIL)。③结果 观察组在TBIL水平、光疗时间、黄疸消退时间均显著低于对照组(P<0.005)。自身对照时观察组治疗前后Hb无明显下降(P>0.05),对照组显著下降(P<0.005)。④结论 早期使用IVIG可有效防止或减轻由新生儿ABO溶血病引起的高胆红素血症和贫血。

Objective Research on the effect of inlravenous immunoglobin for the early treatment of ABO hemolysis. Method ABO hemolysis was diagnosed through test for the umbilical cord. 25 patients were divided into treated group (13 neonatees) and control group (12 neonates). The control group received traditional treatment ,beside treated as the control group,the treated group were given IVIG(800mg/kg · d) one time in postnatal 24 hours. Result The total bilirubin values of the treated group were significantly less than the control group,as well as the time of phototherapy and jaundice disappear(P<0. 01).The Hb value of the control group were significantly drop(P<0. 01), but the treated group were no(P>0. 05). Conclusion The early treatment of IVIG can lighten or avoid high bilirubin in the blood and anemia due to ABO hemolysis.