氧化苦参碱对肝纤维化患者IL-6、IL-8、IL-10水平影响

Influence of matrine on serum levels of IL-6,IL-8,IL-10 in patients with liver fibrosis

目的 :探讨氧化苦参碱对肝纤维化患者血清IL 6、IL 8、IL 10水平影响。方法 :采用ELISA法分别测定肝纤维化患者治疗前后的IL 6、IL 8、IL 10水平。结果 :肝纤维化病人的IL 6、IL 8水平较正常对照组显著升高、IL 10水平则较正常对照组显著降低。采用氧化苦参碱治疗 3月后肝功能好转者IL 6、IL 8水平较治疗前有显著降低 ,IL 10水平升高 ,但无显著差异。结论 :IL 6、IL 8、IL 10水平与肝纤维化患者预后相关 ,其血清水平可作为判断肝纤维化患者预后的指标之一 ,氧化苦参碱对肝纤维化有抑制作用。

Objective:To study the influence of matrine on serum levels of IL 6,IL 8,IL 10 in patients with liver fibrosis.Methods:60 patients with liver fibrosis were divided into two groups,hepatic function of 34 patients was aggravated and 26 cases were restored or near to normal levels after oral matrine therapy for three months.serum levels of IL 6,IL 8,IL 10 were measured by ELISA methods in all these patients before and after therapy and 60 healthy subjects.Results:The serum levels of IL 6,IL 8,IL 10 of patients with liver fibrosis were significantly higher than healthy subjects.The serum levels of IL 6,IL 8 in aggravated hepatic function group after therapy were significantly higher than the levels before the therapy,the serum levels of IL 10 was higher than the level before therapy,but there was no significant difference between them.and there was no significant difference of serum levels of IL 6,IL 8 in restored normal hepatic function group after therapy,but the serum level of IL 10 was significantly higher than the level before therapy in this group.Conclusion:Serum levels of IL 6,IL 8,IL 10 may be correlated with the prognosis of patients with liver fibrosis.They may be taken as one of markers to judge the prognosis of patients with liver fibrosis,matrine may have an important inhibitive role on liver fibrosis.