血纤维蛋白原浓度对心绞痛分型的临床意义

Clinical Significance of Serum Fibrinogen Concentration to the Classification of Angina Pectoris

目的 :探讨血纤维蛋白原浓度测定对心绞痛分型的临床意义。方法 :根据加拿大心脏病学会心绞痛分型标准 ,将2 5 8例入选的心绞痛患者 ,分成不稳定性心绞痛组 (UAP组 ,n=16 2 )及稳定性心绞痛组 (SAP组 ,n=96 ) ,同时测定两组血浆纤维蛋白原浓度。结果 :不稳定性心绞痛组血纤维蛋白原浓度明显高于稳定性心绞痛组 (4 5 8.5 6± 186 .32 ) mg/dl比 (4 0 1.15± 14 8.6 2 ) mg/ dl,P<0 .0 1。结论 :血纤维蛋白原浓度有助于心绞痛的分型 ,纤维蛋白原升高提示 。

Objective:To investigate the clinical significance of serum fibrinogen concentration to the classification of angina pectoris Methods:258 cases of angina pectoris were divided into unstable angina group (UAP group, n =162) and stable angina group (SAP group, n =96) by Canadian Cardovascular:Grading of angina pectoris Their serum fibrinogen were simultaneously measured Results:Serum fibrinogen concentration in UAP group was markedly higher than that in SAP group (458 56±186 32mg/dl vs 401 15±148 62mg/dl, P <0 01) Conclusion:Serum fibrinogen concentration is of great advantage to the classification of angina pectoris The higher serum fibrinogen concentration in UAP group suggests that thrombosis is an important factor which might be related to the pathogenesis of unstable angina