大剂量利福平在家犬体内药动学研究

Study on Pharmacokinetics of Rifampin in Dog after a High Oral Dose

目的 :研究大剂量口服利福平的药动学过程。方法 :对 6只家犬投予不同剂量的利福平 ,取血标本用 HPL C法测定其浓度。结果 :利福平体内过程符合具有一级吸收的一室模型 ,大剂量时较正常剂量利福平药动学参数发生了变化 ,达峰时间延长 ,消除半衰期增大。结论

Objective:To sudy the pharmacokinetics of Rifampin Methods:Two kinds of doses of Rifampin were administered to six dogs and the blood concentration of Rifampin was detected by HPLC Results:The pharmacokinetics of Rifampin was fitted to a one compartment model with first order absorption After a high oral dose of Rifampin,the pharmacokinetics parameters were changed,the time to peak as well as the elimination half life were delayed Conclusion:This study presents useful information for clinical trials