三七总甙对大鼠肺纤维化过程中血浆MIP-1α、MCP-1含量的影响

Effects of Panax notoginseng saponin on macrophage inflammatory protein-1α and monocyte chemoattractant protein-1 in plasma in rats with pulmonary fibrosis

目的 初步探讨三七总甙 (PNS)对肺纤维化大鼠血浆中MIP 1α、MCP 1的抑制作用及其机制。方法 应用酶联免疫吸附试验 (ELISA)测定各实验组大鼠不同时相点血浆中MIP 1α、MCP 1含量的动态变化。结果 肺纤维化模型组各时相点血浆中MIP 1α、MCP 1水平均高于三七总甙组 ,并随病情进展而逐渐升高 ,第 2 8天达最高水平。PNS组MIP 1α、MCP 1受到明显抑制 ,接近对照组。结论 PNS能有效抑制血浆中MIP 1α、MCP 1水平 ,减轻肺泡炎症程度 。

Objective To investigate the effects of Panax notoginseng saponin (PNS) on macrophage inflammatory protein 1α(MIP 1α) and monocyte chemoattractant protein 1(MCP 1) in plasma in rats with pulmonary fibrosis. Methods The dynamic changes of the contents of MIP 1αand MCP 1 in plasma were determined with ELISA. Results The contents of MIP 1α and MCP 1 in plasma were significantly higher in PF group than those in PNS group at most time points(125 pg/ml and 298 pg/ml), and correlated with the development of fibrosis. The contents of MIP 1α and MCP 1, close to those in the control group, were inhibited obviously in PNS group. Conclusion PNS may have effect on the prevention and cure of fibrosis by minimization of the alveolar inflammation due to the effective inhibition of the contents of MIP 1α and MCP 1 in plasma.