摘要
目的合成选择性雌激素受体调节剂盐酸雷洛昔芬。方法以 3 甲氧基苯硫酚 (Ⅰ )和 4 甲氧基 α 溴代苯乙酮 (Ⅱ )为起始原料 ,经 7步主反应合成盐酸雷洛昔芬。结果与结论合成了盐酸雷洛昔芬 ,总收率为 1 0 0 % ,其结构经MS、1 H NMR、1 3C
Objective To synthesize raloxifene hydrochloride,which is a selective estrogen receptor modulator. Methods It was synthesized from 3-methoxybenzenethiol (Ⅰ) and 4-methoxy-α-bromo acetophenone (Ⅱ) in seven steps. Results and Conclusions Raloxifene hydrochloride was synthesized in 10.0% overall yield,and its structure was confirmed by MS, 1H-NMR, 13C-NMR.
出处
《沈阳药科大学学报》
CAS
CSCD
2003年第2期111-113,共3页
Journal of Shenyang Pharmaceutical University
关键词
雌激素受体调节剂
盐酸雷洛昔芬
合成
estrogen receptor modulator
raloxifene hydrochloride
synthesis
