摘要
目的 :研究食管粘膜上皮癌变过程人端粒酶反转录酶(hTRT)和C_myc蛋白的表达 ,并探讨其与食管癌发生的关系。 方法 :应用免疫组化S_P法 ,观察70例食管癌切除新鲜标本的上切缘正常粘膜、癌旁食管粘膜上皮和食管原位癌组织中hTRT和C_myc蛋白的表达情况。 结果 :hTRT和C_myc在增生和恶变的食管粘膜上皮细胞表达 ,两者在食管癌变过程显示相同的分布模式。 结论 :端粒酶hTRT和C_myc蛋白的表达与食管粘膜上皮的恶性转化密切相关 。
Purpose: To investigate the expression of human telomerase reverse transcriptase (hTRT) and C_myc in esophageal epitheliosis and carconogenesis, and their relation to the development of esophageal carcinoma. Methods: Telomerase hTRT and C_myc protein expression in 70 fresh tissue specimen, including esophageal mucosa above the upper surgical margin, carcinoma in situ and mucosa adjacent to tumor, were detected using immunohistochemical method. Results: hTRT and C_myc protein were expressed in proliferating and transformed malignant cells of esophageal epithelium. The expression of C_myc protein showed a similar distribution pattern to that of hTRT. Conclusion: Telomerase hTRT and C_myc protein expressions are closely related to the malignant transformation of esophageal epithelium. The reactivated telomerase and up_regulated C_myc may play a crucial role in the development of esophageal carcinoma.[
出处
《癌变．畸变．突变》
CAS
CSCD
2003年第1期17-20,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
