(Z)-2-(2-氨基-4-噻唑)-2-羟亚胺基乙酸乙酯的合成工艺改进

Improvement on the Synthesis of Ethyl (Z)-2-(2-amino-4-thiazolyl)-2-hydroximinoacetate.

以乙酰乙酸乙酯为原料 ,经亚硝化、溴化、环合连续反应制得 (Z) 2 (2 氨基 4 噻唑 ) 2 羟亚氨基乙酸乙酯 ,总收率为 76 73% ,含量为 98 5 %。对合成工艺进行了改进 ,简化了操作 ,提高了反应收率。

The ethyl(Z)-2-(2-amino-4-thiazolyl)-2-hydroximinoacetate was synthesized by nitrition, bromation and cyclization from ethyl acetoacetate in total yield of 76.7% and content of 98.8%. The synthetic process was improved, operation was simplified and yield was increased.