肥胖症与脂质代谢

Obesity and lipid metabolism

肥胖是一种常见疾病 ,是体内脂肪过多的表现 ,与脂质代谢紊乱密切相关 ,二者互为因果。其脂质代谢紊乱表现为摄食过多使脂肪合成的原料增加 ,棕色脂肪含量减少使能量消耗减少素和降脂激素调节失常使脂肪合成增加、降解减少。同时也可由于脂肪动员增加使血中游离脂肪酸、甘油三酯增加 ,极低密度脂蛋白和低密度脂蛋白清除减少。高胰岛素血症和胰岛素抵抗既是肥胖的结果 ,也是肥胖患者脂质代谢紊乱的主要原因 。

Obesity is a common disease showing excessive body fat ,and is closely associated with the disorder of lipid metabolism. The lipid metabolism disorder of obesity results from excessive ingestion,which make fat synthetic material increase. Moreover brown fat tissue of obesity patient decrease, which cause energy expenditure to reduce. In the meantime fat synthesis increases and lipolysis decreases because of regulative disturbance of hormones about lipogenesis and lipolysis. Since fat mobilization inccreases,free fatty acid and triacylglycerol augment;very low density lipoprotein and low density lipoprotein are cleared away less.Both high insulinemia and insulin resistance is the result of obesity and the main reason of lipid metabolism disorder in obesity patients.Other factors such as leptin also play an important role in lipid metabolism disorder of obesity . \