中年高血压病视网膜中央动脉彩色多普勒频谱研究

A Research of Doppler profiles of central Retinal Artery in Midage Hypertension.

目的 研究中年高血压病不同危险层次患者视网膜中央动脉血流动力学变化规律。方法 应用彩色多普勒检测 3 79例中年正常人和 80 7例不同危险层次中年高血压病患者视网膜中央动脉血流频谱 ,测定收缩期峰值流速(PSV) ,舒张末期血流速度 (EDV) ,阻力指数 (RI)和搏动指数 (PI)。结果 高血压病与正常对照组PSV、EDV、RI、PI比较均有显著差异 (P <0 .0 1) ,高血压病患者视网膜中央动脉呈低流量、高阻力型改变。低危与中危者各参数相比无显著差异(P >0 .0 5 )。危险层次至中危后 ,随着危险层次的提高 ,PSV、EDV逐渐减低 ,RI、PI逐渐升高 (P <0 .0 1或P <0 .0 5 )。结论彩色多普勒能反映高血压病不同危险层次患者视网膜中央动脉血流动力学状况 。

Objective To evaluate the hemodynamic changes of central retinal artery(CRA)in midage patients with hypertension and identify the population at risk.Methods 807 patients with hypertension and 379 midage normal persons were detected the profiles of CRA by color Dopple ultrasonography.Risk stratification depended on the blood pressure level and factors that may infect the prognosis of hypertension according to the standard of WHO/ISH hypertension committee 1999.Among 807 hypertensions,therre are 251 cases in low risk group,334 cases in moderate risk group,176 cases in high risk group and 46 cases in very high risk.We measured the peak systolic velocity(PSV),end-diastolic velocity(EDV),resistance index(RI)and pulsatility index (PI)of CRA.Results There was significant difference in PSV,EDV,RI,PI between hypertension group and control group(P<0.01).No significant difference of above parameters was found between low risk group and moderate risk group.However,accompany with the risk stratification increasing(worse than moderate risk),the PSV and EDV became lower and RI,PI were higher (P<0.05-0.01).Conclusions Color Doppler can accurately reveal the hemodynamic changes of CRA in difference risk stratification group of hypertension.It is a useful clinic quantitative method to evaluate the severity of hypertension.