新生儿细菌感染时血清TNF-α和IL-10水平变化

The changes of serum TNF-α and IL-10 in neonates with bacterial infections

为了解血清TNF_α和IL_10的水平与新生儿感染状态和预后的关系 ,将2000年1月～2002年1月新生儿病房收治的足月儿207例 ,分为败血症组82例 ,一般感染组98例 ,非感染组27例 ,用ELISA法检测血清TNF_α和IL_10水平。结果显示 ,败血症组的TNF_α、IL_10水平显著高于无感染组和一般感染组 ;血培养阳性和血培养阴性的败血症组之间TNF_α和IL_10水平差异无显著性 ;IL_10的水平和IL_10/TNF_α的比值在恶化或死亡的感染病例中显著升高。

To evaluate the serum concentrations of TNF_α and IL_10 in neonates with bacterial infections and also the relationship of the ratio of IL_10/TNF_α and prognosis in infected neonates,207 term neonates admitted during 2000.1～ 2002.1 in Children's Hospital,were entered into study deviding to:sepsis group(82),general infectious group(98) and non_ infectious group(27).TNF_α and IL_10 were measured by ELISA.The concentrations of TNF_α and IL_10 significantly increased in sepsis group,and there was no difference between septic neonates with or without positive blood culture.Infectious neonates with poor prognosis had higher serum IL_10 and higher ratio of IL_10/TNF_α.The changes of TNF_α and IL_10 in serum indicate that they may more sensitively reflect the presence of infection and the prognosis of the infection.