青年夜尿游离皮质醇与原发性高血压的关系

Relation Between Night Urinary Free Cortisol and Hypertension in Youth

目的 :研究青年夜尿游离皮质醇的排泄量与原发性高血压的关系。方法 :对 188名青年进行血压及相关因素、夜 8小时尿游离皮质醇的测定。结果 :青年男性原发性高血压者夜 8小时尿游离皮质醇的排泄量显著高于血压正常者 ( 2 1 5 7± 6 2 8μg/8h对 10 5 4± 5 46μg/8h ,P <0 0 5 ) ;高血压家族史阳性者显著高于高血压家族史阴性者 ,在男、女性中分别为 16 90± 6 5 0 μg/8h对 9 44± 4 95 μg/8h(P <0 0 5 ) ,10 5 4± 5 46μg/8h对 6 2 2± 3 18μg/8h(P <0 0 5 ) ;男性明显高于女性 ,12 73± 5 85μg/8h对 7 80± 4 15 μg/8h(P <0 0 5 )。结论 :青年男性高血压者夜 8小时尿游离皮质醇的排泄量明显高于血压正常者 ,夜尿游离皮质醇的排泄量与高血压的家族史相关联 ,且存在明显的性别差异。提示青年高血压患者及其易感者中已存在皮质醇代谢的异常 ,糖皮质激素可能参与高血压的发病过程。

Objective:To study the relation between night urinary free cortisol (UFC) excretion and essential hypertension in youth.Methods:Night UFC and blood pressure related factors were measured in 188 young people Results:In young men with hypertension the night UFC in 8 hours was significantly higher than those with normal blood pressure (21 57±6 28 μg/8h vs 10 54±5 46 μg/8h, p <0 05) In the young people with positive family history of hypertension,the night UFC was much higher than those with negative family history of hypertension Males excreted much more night UFC than females(12 73±5 85 μg/8h vs 7 80±4 15 μg/8h, p <0 05) Conclusion:There is an association between hypertension and high night UFC excretion This association might have a genetic basis Furthermore,there is gender difference in night UFC excretion