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乙型肝炎病毒核心抗原与前S1抗原融合蛋白诱导小鼠免疫反应的实验研究 被引量：5

Immune response in mice induced by the fusion protein of HBcAg and HBV PreSl
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摘要 采用基因重组技术表达了去除C末端的HBV核心抗原和前S1抗原融合蛋白,经免疫印迹试验表明其具有特异抗原反应性[1].进一步用该融合抗原免疫BALB/C小鼠,观察其诱导小鼠特异性体液免疫产生情况.
作者 陈心春 周伯平 李美忠 王召钦 王火生 张斌 唐蔚
机构地区 深圳市肝病研究所
出处 《中华肝脏病杂志》 CAS CSCD 2003年第3期184-185,共2页 Chinese Journal of Hepatology
关键词 乙型肝炎病毒 核心抗原 前S1抗原 融合蛋白 小鼠 体液免疫 Hepatitis B virus Core antigen PreSl Humoral immunity Mice
分类号 R512.62 [医药卫生—内科学] R373.21 [医药卫生—病原生物学]
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二级参考文献8

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共引文献5

同被引文献78

  • 1骆利敏,李明,夏虎,黄建生,陈百虹,王萍.乙型肝炎病毒多表位治疗性抗原基因的合成、表达及抗原性研究[J].第一军医大学学报,2003,23(8):802-805. 被引量：7
  • 2姚伟,刘广洋,任雅平,李玉,张岩锐,任魁,沈心亮.重组HBcAg与HBsAg混合抗原的免疫效果[J].中国生物制品学杂志,2007,20(3):198-200. 被引量：3
  • 3Kang ES, Kim CY, Kim SB, et al. In vivo kinetics and biodistri- bution of HB-110, a novel HBV DNA vaccine, after administration in mice [Jl. Arch Phama Res, 2007, 30 (3): 355-360.
  • 4Kim CY, Kang ES, Kim SB, et al. Increased in viva immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation [J]. Exp Mol Med, 2008, 40 (6): 669-676.
  • 5Liu S, He J, Shih C, et al. Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths [J]. Virus Res, 2010, 149 (2):241-244.
  • 6Cao T, Lazdina U, Desombere I, et al. Hepatitis B virus core antigen binds and activates naive human B cells in vivo: studies with a human PBL-NOD/SCID mouse model [J]. J Virol, 2001, 75 (14): 6359-6366.
  • 7Kang H, Yu J, Jung G. Phosphorylation of hepatitis B virus core C-terminally truncated protein (Cp149) by PKC increases capsid assembly and stability [J]. Biochem J, 2008, 416 (1): 47-54.
  • 8Bimbaum F, Nassal M. Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein [J]. J Virol, 1990, 64(7): 3319-3330.
  • 9Riedl P, Stober D, Oehninger C, et al. Priming Thlimmunity to viral core particles is facilitated by trace amounts of RNA bound to its arginine-rich domain [J]. J hnmunol, 2002, 168 (10): 4951- 4959.
  • 10Chen X, Li M, Le X, et al. Recombinant hepatitis B core antigen carrying preS1 epitopes induce immune response against chronic HBV infection [J]. Vaccine, 2004, 22 (3-4): 439-446.

引证文献5

二级引证文献13

中华肝脏病杂志
2003年 第3期

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