uPA和KDR在髓母细胞瘤中的表达及意义

Expression and significance of urokinase-type plasminogen activator and KDR in medulloblastoma

目的 研究尿激酶型纤溶酶原激活剂 (urokinase typeplasminogenactivator,uPA)和KDR(vascularendotheliagrowthfactorreceptor 2 )在髓母细胞瘤中的表达及临床意义。方法 应用免疫组化LSAB法检测 50例髓母细胞瘤中uPA和KDR的表达 ,结合临床随访 ,使用Cox回归统计分析和Spear man相关分析。结果 uPA和KDR的染色定位于肿瘤细胞和血管内皮细胞。Cox回归分析显示uPA和KDR是影响生存时间的独立的预后因子 ,它与预后存在高度负相关关系。Spearman相关分析显示uPA和KDR存在正相关关系。结论 uPA和KDR可能是预测髓母细胞瘤预后的独立的预后因子。

Objective To study expression and clinical significance of urokinase type plasminogen activator (uPA ) and KDR in medulloblastoma. Methods Applying LSAB( labelled streptavidin biotin method) immunohistochemical technique, expression of uPA and KDR were studied in 50 patients with medulloblastoma. The results were summarized by follow up survey with Cox regression analysis and Spearman correlation analysis.Results The staining for uPA and KDR were localized on tumor cells and endothelial cells.Cox regression analysis documented that the uPA and KDA were independent prognostic factor affecting survival, and they had a negative correlation with the prognosis. Moreorer, UPA had a positive correlation with KDR. Conclusions UPA and KDR appeared to be the independent marker for predicting prognosis of medulloblastoma. UPA had a positive correlation with KDR.