摘要
为探讨脑胶质瘤生物治疗的新方法,本研究从四个不同方面对脑胶质瘤的生物学特性进行了研究。结果表明,人脑胶质瘤存在IL-6的自分泌环路,打断该环路可抑制脑胶质瘤的生长;脑胶质瘤组织和脑胶质瘤细胞均存在明显的Th2类细胞因子优势表达,Th2向Th1方向逆转后可以抑制脑胶质瘤细胞的增殖;红霉素在逆转耐药中以100μg/ml疗效最佳;血管生长抑制因子(angiostatin)不仅能在体外抑制内皮细胞生长,而且在体内亦有明显的抑瘤作用。上述研究结果为脑胶质瘤的治疗提供了新的思路,将有望应用于临床,提高脑胶质瘤患者的治疗效果。
In order to explore the new methods of biological treatment of human gliomas,this project is to study the biological properties of gliomas from four different aspects,the results show that there is a IL-6autocrine loop in human gliomas and the growth of gliomas will be inhibited when the autocrine loop is broken.There is a magnificent predominant expression of Th2cytokines in human gliomas and human glioma cells,the switching of Th2to Th1can inhibit the proliferation of glioma cells.The dosage of100μg/ml of erythromycin is the best of therapeutic effect.Angiostatin can not only inhibit the vascular endothelial growth,but also have the inhibitory role on the growth of glioma cells in vivo.The above studies have provided some new ideas and will be very helpful for the treatment of glioma patients.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2003年第1期88-92,共5页
Acta Academiae Medicinae Sinicae
基金
山东省医药卫生九五攻关课题(鲁卫攻关08号)
国家自然科学基金(30070272)资助~
