褪黑激素的抗肿瘤活性研究

Study on the anti-tumor activity of melatonin

目的 研究褪黑激素对 S180 荷瘤小鼠肿瘤的抑制作用。方法 通过给小鼠接种 S180 瘤后 ,观察不同剂量褪黑激素对小鼠肿瘤瘤重及其体质量、肝、脾指数、白细胞数的影响。结果 褪黑激素大、中、小剂量组对 S180 荷瘤小鼠肿瘤均具有显著的抑制作用 (P <0 .0 1 ) ,且无降低小鼠体质量、肝、脾指数及白细胞数的作用。结论 褪黑激素对 S180 肿瘤具有抑制作用 。

Objective To study the anti-tumor effect of melatonin on S 180 tumor. Methods The inhibitory rate, liver index, spleen index and white blood cell of mouse treated with various concentration of melatonin on S 180 tumor were determined in this paper. Results The anti-tumor effect of melatonin group was higher significantly than that of negative group (P<0.01) and melatonin group could avoid the side-effects of the common anti-tumor medicines. Conclusion The results indicated that melatonin can inhibit neoplasm and have potentiality to become an anti-tumor medicine.