颈动脉粥样硬化与脑梗死的相关性

Preliminary Study on the Correlation between Carotid Atherosclerosis and Cerebral Infarction

目的 本文旨在探讨颈动脉内膜 中膜厚度 (IMT)增厚和斑块形成的相关危险因素及其与脑梗死之间的关系。方法 应用颈动脉B超技术 ,对 2 84例意识清晰的脑梗死和非脑血管病住院患者的颈动脉IMT和斑块进行检测。结果 Logistic回归分析发现随着年龄的增大 ,颈动脉斑块的发生率明显增加 (P <0 .0 0 1)。高血压、糖尿病及血纤维蛋白原水平与颈动脉斑块形成有密切联系 (P <0 .0 5 )。但是血糖和血脂水平与斑块的形成无明确关系。颈动脉斑块组和非斑块组的吸烟、饮酒、性别和心电图缺血改变无明显差异。脑梗死患者颈动脉斑块的发生率明显增加 (P =0 .0 15 ) ,颈总、内动脉IMT显著增厚。结论 颈动脉IMT增厚和斑块形成是多因素相互作用的结果 。

Objective To investigate the risk factors of atherosclerotic plaques and an increased intima-media thickness (IMT) in the carotid artery and to clarify the relationship between IMT or/and plaque and cerebral infarction.Methods B-mode ultrasonographic techniques were used to measure the plaques and IMT of the carotid artery in 284 cases including conscious hospitalized patients with CI and patients without cerebrovascular disease.Results By Logistic regression analysis, we found carotid plaque increased progressively with age(P=0.000).It was correlated to high blood pressure, diabetes and increased fibrinogen level (P<0.05). No relationship was found between plaque and blood sugar and blood lipid levels. There was no significant difference between plaque group and no plaque group in smoking, drinking, gender and ischemic change of EKG. IMT of common carotid artery (CCA) and internal carotid artery (ICA) was significantly thicker and the incidence of carotid plaque in CI group was significantly higher than that in the control.Conclusion Increased CA?IMT and plaque are important risk factors of CI and many factors are contributed to them.