伊贝沙坦治疗老年高血压病

Efficacy of Irbesartan in Gerontal Patients with Hypertension

目的 观察伊贝沙坦和卡托普利对老年原发性高血压患者的降压作用及内生肌酐清除率 (Cr-C)的影响。方法 选择 6 8例老年原发性高血压患者 ,Cr -C在 5 0 .0ml± 19.4ml/ (min·1.73m2 ) - 1之间。随机分成伊贝沙坦组 (n =34)、卡托普利组 (n =34) ,对 2组分别进行治疗前、后降压幅度、Cr -C的比较。结果 伊贝沙坦和卡托普利对于老年原发性高血压的降压作用同样有效 ,但前者提高Cr-C的作用明显优于后者 ,2组比较有显著差异性 (P <0 .0 1)。伊贝沙坦组未见干咳现象 ,卡托普利组干咳发生率为 17.6 %。结论 伊贝沙坦不仅有良好的降压作用 ,还能较卡托普利更好地提高Cr-C、改善肾功。

Objective To investigate the antihypertensive effect of irbesartan on gerontal patients with hypertension and to seek its effect on endogenous creatinine clearance (Cr-c). Methods 68 gerontal patients with hypertension (Cr-c were between 50.0(19.4ml/min(1.73m 2) were randomly divided into 2 groups: irbesartan group and captopril group 34 cases per each. The values of blood pressure and Cr-c were measured before and after treatment. Results Irbesartan group and captopril group had the same antihypertensive effect on gerontal patients, but the former improved Cr-c more better than the later. There was significant difference between the two groups (P<0.01). Irbesartan group had no unproductive cough, but it was seen in captopril group (incidence was 17.6%). Conclusion Irbesartan not only has the very good antihypertensive effect but also has the effect of improvement of Cr-c and renal function.