口腔鳞癌患者血清一氧化氮水平及其手术前后的变化

Serum nitric oxide level in the patients with oral squamous cell carcinoma and its change after operation

目的 :探讨口腔鳞癌患者血清一氧化氮水平及手术前后的变化和意义。方法 :采用化学比色法对 41例口腔鳞癌、31例口腔颈面部良性肿瘤及 2 0例健康人血清一氧化氮 (NO)和一氧化氮合成酶 (NOS)水平进行了检测。结果 :口腔鳞癌组血清NO和NOS水平显著高于良性病变组和健康对照组 (P <0 .0 5) ,口腔鳞癌组中NO和NOS水平在有颈淋巴结转移者显著高于无颈淋巴结转移者 (P <0 .0 5) ,病变切除手术后NO及NOS显著低于手术前 (P <0 .0 5)。结论 :NO和NOS与口腔鳞癌的发生、发展有密切关系 。

Purpose:To study the serum nitric oxide level and changes before and after operation in patients with oral squamous cell carcinoma.Methods:Serum NO and nitric oxide synthase(NOS) in 41 patients with oral squamous cell carcinoma,31 cases of benign diseases and 20 healthy coutrol were measured by chemical photometry.Results:In oral squamous cell carcinoma group,the serum NO and NOS level were significantly higher than in benign diseases and healthy control group ( P<0.05).The NO and NOS contents in cervical lymph node metastasis group increased signficantly as compared to the cervical lymph node negative group( P <0 05).The NO and NOS levels decreased significantly 2 weeks after operation( P <0 05).Conclusions:The serum NO and NOS levels is closely related to occurence and development of oral squamous cell carcinoma.Detection of serum NO and NOS is useful in the judgement of patients′ condition and is a guide to treatment of oral squamous cell carcinema.