摘要
目的 :研究并测定乙醇对大鼠杏仁核点燃的抑制作用。方法 :建立大鼠杏仁核点燃模型 ,观察乙醇对点燃发展及发作的影响 ,并通过联合用药探讨乙醇对点燃的作用及其可能机制。结果 :乙醇 0 .5～ 1 .5g·kg 1 皮下注射均能升高杏仁核点燃后放电阈值 ,降低Racine发作强度和全身发作的百分率 ,抑制点燃发展进程 (P <0 .0 1 )和点燃发作 (P <0 .0 5)。在对点燃均无明显影响的低剂量下 ,乙醇与地西泮或苯巴比妥合用对后放电时程和Racine分级无明显影响。结论 :乙醇对大鼠杏仁核点燃发作及其发展有抑制作用 。
Objective:To investigate and observe the inhibitory effect of alcohol on seizure activity in kindled rats. Method:The effect and mechanism of alcohol on kindling and its development were examined by the establishment of amygdala kindling model and combination with other drugs. Results:Alcohol, at doses of 0.5 to 1.5 g·kg 1 , ip, increased the focal threshold after discharge, reduced the Racine's degrees, seizure severity and the percentage of generalized seizure. Compared with the control group, the alcohol groups inhibited the development of kindling ( P <0.01) and seizure activity in kindled rats( P <0.05). The combination of alcohol with phenobarbital or diazepam, all at ineffective doses on kindling, showed no significant effects on ADD and Racine's degree. Conclusion:Alcohol can inhibit the progress of kindling and seizure activity in amygdaloid kindled rats,but at ineffective doses on kindling, has no synergism with phenobarbital or diazepam.
出处
《医药导报》
CAS
2003年第3期145-147,共3页
Herald of Medicine
关键词
乙醇
地西泮
点燃
杏仁核
抑制作用
Alcohol
Diazepam
Kindling
Amygdaloid
Inhibitory effect
