参七胶囊治疗高血压及脑血管血流动力学研究

A Clinical Study on the Effect of Salvia-notoginseng Capsule on Cerebral Vascular Hemodynamics in Hypertension

目的 :观察参七胶囊治疗原发性高血压的临床疗效及脑血管血流动力学 (CVA)参数变化。方法 :治疗组62例 ,口服参七胶囊 1 .8g ,bid ;对照组 50例 ,口服卡托普利 2 5mg,tid ;两组均连续服 90d。观察治疗前后血压、CVA参数变化。结果 :治疗组收缩压 (SBP)由 (1 57.9± 2 4 .2 )mmHg下降至 (1 4 0 .9± 1 3 .2 )mmHg ;舒张压 (DBP)由 (94.7± 9.8)mmHg下降至 (87.6± 7.8)mmHg ,降压疗效与对照组相当 (96 .8% 96 .0 % ,P >0 .0 5) ,但治疗后治疗组CVA参数改善明显 ,与对照组比较差异有极显著性 (χ2 =54.8,P <0 .0 1 ) ;随访结果表明 ,治疗组在脑卒中发生率 (0 4.44% ) ,血压不稳率(0 6 .52 % )等方面与对照组比较差异有显著性 (χ2 =4.8,P <0 .0 5)。结论 :参七胶囊降压效果缓慢持久 ,疗效可靠 ,且能改善CVA各项参数 ,保护大脑 。

Objective:To observe the clinical therapeutic effect and change of the cerebral vascular hymodynamics analyzing(CVA) index of hypertension with salvia notoginseng capsule. Methods:62 cases (observation group) took salvia notoginseng capsule 1.8 g each time, twice daily, while another 50 cases as control group took captopril, 25 mg each time 3 times daily, all for 90 days. Blood pressure and the index of CVA such as Q mean , V max , V mean , V min , Zcv, Wv, DI, Rv, SP, DP during the period of treatment were recorded. Results:It was observed that the systolic pressure (SBP) of the observation group was lowered down from (157.9±24.2) mmHg to (140.9±13.2) mmHg, diastolic pressure (DBP) from (94.7±9.8) mmHg to (87.6±7.8) mmHg with a similar effect to the control group (96.8%/96.0%, P >0.05). More important, it was found that CVA index of the observation group had a significant change when compared to the control group (χ 2=54.8, P<0.01). The follow ups showed that the morbidity of stroke and frequency of blood pressure unstability were lower in the observation group than those in the control group (0/4.44%; 0/6.52%, χ 2=4.8, P <0.05). Conclusion: Salvia notoginseng has a slow but lasting and reliable effect on lowering the hypertension. It also improves the index of CVA and can prevent strokes from occurring.