急性脑梗死患者血清TNF-α、IL-1β和sICAM-1含量变化

Changes of serum tumor necrosis factor-α,interleukin-1 β,and soluble intercellular adhesion molecule-1 in patients with cerebral infarction

目的 观察脑梗死患者血清TNF α、IL 1β和sICAM 1含量的变化及意义。 方法 采用双抗体夹心酶联免疫吸附法 (ELISA)测定 5 0例脑梗死患者急性期、恢复期血清中TNF α、IL 1β和sICAM 1含量 ,并与 4 0例正常对照组比较。结果 急性期、恢复期脑梗死患者血清TNF α、IL 1β和sICAM 1水平较对照组显著增高 (P <0 0 1) ,急性期又较恢复期高 (P <0 0 5 ) ,增高程度与神经功能缺损程度及梗死体积大小密切相关 ,且血清中TNF α含量与IL 1β和sICAM 1也相关。 结论 TNF α、IL 1β和sICAM -

Objective To observe the changes in serum lecel of tumor necrosis factor α(TNF α),interleukin 1 β(IL 1 β),and soluble intercellular adhesion molecule 1(sICAM 1)between acute phase and recovery phase of patients with cerebral infarction.Methods Serum levels of TNF α,Il 1 β,and sICAM 1 were measured by enzyme linked immunosorbent assay(ELISA).Results Serum levels of TNF α,IL 1 β,and sICAM 1 in patients with cerebral infarctions of acute phase and recovery phase increased remarkably ascompared with control group( P <0 001, P <0 05).The levels in patients during the acute phase also increased remarkably as compared with recovery phase( P <0 05, P <0 01).There was a positive correlation among the extent of infarction,the degree neurological deficits and different infarct volumes.On the other hand,a positive correlation was found among sICAM 1,TNF α and IL 1β.Conclusion TNF-α,IL-1 β,and sICAM-1 possibly play a role in the inflammatory reaction in early cerebra infarction and the damage after reperfusion. [