系统性红斑狼疮患者合并丙型肝炎病毒感染的临床分析

Clinical analysis of patients with systemic lupus erythematosus and hepatitis C

目的:确定系统性红斑狼疮(SLE)患者丙型肝炎病毒(HCV)感染的发病率及其临床意义。方法:用ELISA-3、RIBA-3及PCR检测134例SLE和200名正常献血者HCV感染情况。结果:15例SLE患者(11%)和2名对照组(1%)HCV抗体阳性(P<0.001),SLE患者合并HCV感染率明显高于对照组,合并HCV感染SLE患者的皮肤表现、ds-DNA抗体发生率低(P=0.01,P<0.001),肝脏损害、低补体血症、冷球蛋白血症发生率高(P<0.001,P=0.002,P=0.03,P=0.02)。结论:SLE患者的HCV感染率高于正常人群。

Objective:To determine the prevalence and clinical significance of hepatitis C virus(HCV)infection in patients with systemic lupus erythematosus(SLE).Methods:Anti-HCV antibodies of sera were detected by using the meth ods of ELISA-3,RIBA-3and PCR in134patients with SLE and200blood donors.Results:HCV infections were found in15(11%)patients with SLE and in2(1%)controls,which was significant higher in SLE group than that in con trol(P<0.001).Comparing the SLE patients with no HCV infection,HCV infected SLE patients showed the lower fre-quen cies of SLE cutaneous lesions and the positive reac tions to anti-dsDNA antibodies(P=0.01,P<0.001),and they often had hep atic in volvement,low levels of C4and CH50(P<0.001,P=0.002,P=0.03)and cryoglobulins(P<0.001,P=0.02).Conclu sion:The ra tio of HCV infection was higher in the patients with SLE than that in the normal control.