猕猴颈内动脉系实验性动脉粥样硬化的扫描电镜观察

Scanning Electron Microscopic Study of Experimental Atherosclerosis in the Monkey Internal Carotid System

用高脂饮食喂养雄性猕猴达17个月,扫描电镜观察从颈总动脉分叉处到大脑前、中动脉的内膜面,发现在颈总动脉分叉部,颈内动脉颅外、颅内段,Willis环处有脂斑形成。最严重的损害位于颈总动脉分叉部。颅外动脉损害较颅内动脉严重。大脑前、中动脉损害与其它动脉比较,无论范围或程度都稍轻。Willis环以及起始于它的中央支开口处发现动脉粥样硬化灶。这可能与局部的血流动力学因素有关。

The high fat and cholesterol diet fed male rhesus monkeys for 17 months;.Using scanning elec- tron microscopy we examined the endothelial surfaces covering from the bifurcation of common carotid artery to anterior,middle cerebral arteries.The fatty plaques were observed in the bifurcation of com- mon carotid artery' intracranial and extracranial segments of internal carotid artery,circle of willis.The Largest lesions were located at bifurcation of common carotid artery.The severity of lesions was found more in extracranial arteries than in intracranial arteries.The lesions in the anterior,middle cerebral arteries were milder in extent and severity as compared to other arteries.The circle of willis and the regions of its branching were favored sites for the development of cerebral atherosclerosis.The local hemodynamic factors were closely related to the localization of atherosclerosis.