慢性丙型肝炎与Ⅱ型糖尿病关系的研究

Relationship between chronic hepatitis C and type Ⅱ diabetes mellitus

目的 探讨慢性丙型肝炎病毒 (HCV)感染与Ⅱ型糖尿病发病的关系。方法 ①对 2 2 7例慢性乙型肝炎 (乙型肝炎后肝硬化 86例 )与 12 6例慢性丙型肝炎患者 (丙型肝炎后肝硬化 3 0例 )进行病例分析研究 ,明确其是否合并糖尿病。②用ELISA方法对 160例Ⅱ型糖尿病患者及 2 2 3例体检人群进行抗HCV、HBsAg检测。结果 ① 12 6例慢性丙型肝炎患者合并Ⅱ型糖尿病 2 4例 (19.0 5 % ) ,2 2 7例慢性乙型肝炎患者合并Ⅱ型糖尿病 19例 (8.3 7% ) ,二者比较差异有显著性 (P <0 .0 1) ,年龄及丙型肝炎为发生糖尿病的独立危险因素。② 160例Ⅱ型糖尿病患者中抗HCV阳性 5例 (3 .12 % ) ,HBsAg阳性 7例 (4 3 7% ) ,2 2 3例体检人群抗HCV阳性 0例 ,与糖尿病人群差异有显著性 (P <0 .0 5 ) ,HBsAg阳性 12例 (5 .3 8% ) ,与糖尿病人群差异无显著性 (P >0 .0 5 )。结论 ①慢性丙型肝炎病毒感染易合并Ⅱ型糖尿病。②Ⅱ型糖尿病患者中丙型肝炎感染率高于普通人群 ,提示HCV感染与糖尿病的发生有一定关系 。

Objective To study the relationship between HCV infection and the development of type Ⅱ diabetes mellitus. Methods 1.The case record files of 126 patients with chronic hepatitis C vs. 227 with chronic hepatitis B were reviewed and the laboratory and demographic data were extracted. 2. Anti HCV and HBsAg were determined for 160 type Ⅱ diabetes patients and 223 healthy adults by ELISA. Results 1. The occurrence of diabetes in patients with chronic hepatitis C was 19.05%, higher than 8.37% in patients with chronic hepatitis B ( P <0.01). Age and HCV infection were independent risk factors for diabetes. 2. Five patients with type Ⅱ diabetes were anti HCV positive (3.12%) while none of the 223 healthy adults was anti HCV positive ( P <0.05). Seven patients with diabetes (4.37%) and 12 healthy adults (5.38%)were HBsAg positive ( P >0.05). Conclusions 1. The occurrence of diabetes was significantly higher in patients with HCV related liver disease than in patients with HBV related liver disease. 2. The occurrence of anti HCV was higher in diabetes patients than in healthy adults.HCV may play a role in the development of diabetes mellitus.