应用多普勒组织成像评价肥厚型心肌病心功能

Assessment of left ventricular function in hypertrophic cardiomyopathy with Doppler tissue imaging

目的 应用多普勒组织成像脉冲技术测量二尖瓣环舒缩速度 ,以评价肥厚型心肌病心功能改变。方法 按左心室流出道是否梗阻分为梗阻性与非梗阻性肥厚型心肌病 ,分别测量正常人、梗阻性及非梗阻性肥厚型心肌病 3组二尖瓣环各点收缩期峰值速度 (Sa)、舒张早期峰值速度 (Ea)、舒张晚期峰值速度 (Aa)。结果 梗阻性与非梗阻性肥厚型心肌病患者与正常组Ea、Sa比较差异均有显著性意义 (P <0 .0 0 1) ,Aa差异则无显著性意义 (P >0 .0 5 )。梗阻性与非梗阻性肥厚型心肌病间Ea差异有显著性意义(P <0 .0 5 ) ,Sa、Aa差异无显著性意义 (P >0 .0 5 )。结论 肥厚型心肌病左心室长轴收缩功能及主动松弛功能较正常人减低。梗阻性较非梗阻性肥厚型心肌病左心室主动松弛功能减低。

Objective To evaluate left ventricular function in patients with hypertrophic cardiomyopathy(HCM). Methods The velocity of mitral annular was measured by Doppler tissue pulsed wave mode. Doppler tissue imaging(DTI) was obtained by using the apical window at 4-chamber,2-chamber and long apical views to measure Ea,Aa,Sa, respectively. Ea,Aa,Sa of normal group was compared with those of group of obstructive hypertrophic cardiomyopathy and non-obstructive hypertrophic cardiomyopathy. Results There were differences in Sa,Ea between normal group and hypertrophic cardiomyopathy( P < 0.001 ), but no differences were found in Aa( P > 0.05 ). Obstrautive hypertrophic cardiomyopathy had differences in Ea with non-obstrutive hypertrophic cardiomyopathy( P < 0.05 ), but no differences in Sa,Aa( P > 0.05 ).Conclusions Hypertrophic cardiomyopathy decreased in left ventricular function. There were differences in relaxtion of left ventricular between non-obstructive hypertrophic cardiomyopathy and obstructive hypertrophic cardiomyopathy.