白血病细胞相关抑制物对红细胞系造血影响的初步探讨

PRELIMINARY STUDY OF THE EFFECT OF LEUKEMIC-CELL ASSOCIATED INHIBITOR ON NORMAL CFU-E

白血病细胞相关抑制物(LAI)对正常粒-巨噬系祖细胞(CFU-GM)生长有抑制作用,国内外近年已有较多报道。在体外CFU-GM培养中加入白血病细胞条件培养液,正常CFU-GM的生长受明显抑制,而LAI对正常红系造血的影响报道不多。

CFU-E cutlure in vitro was used to research the suppression of leukemic-cell associated inhibitor on CFU-E. The influence of leukemic-cell conditioned medium (LCCM) from 10 cases of untreated acute leukemic patients was reported. 10/10 LCCM specimen showed inhibition on normal CFU-E growth inuitro. The inhibition rate ranged from 25.4% to 67.4%, and averaged 44.35%. The result in dicated that leukemic-cell associated inhibitor also has inhibitory activity on normal erythropoiesis.