胎儿胸腺细胞移植治疗顽固性Ⅱ型肾病综合征10例初报

FETAL THYMIC CELLS TRANSPLATANTION FOR 10 CASES OF TYPE Ⅱ OBSTINATE NEPHROTIC SYNDROME

众所周知,胸腺是机体的免疫中枢器官,参与T淋巴细胞的免疫调节。自70年代开始应用胸腺移植治疗免疫性缺陷和恶性肿瘤,80年代应用更为广泛,除恶性肿瘤。

We used fetal thymic cells transplantation for the obstinate proteinuria of the 10 cases of nephrotic syndrome, and analysed the urine and blood of the patients before and after trasplantation: the patients' uric protein markedly reduced from 7.69±2.19g/24h to 0.25±0.02g/24h. In blood, hemoglobin increased from 89.6±4.5g/L to 114.3±17.5 g/L, the number of lymphocytes from (1.49 ±0.64) ×10~9/L to (2.66±0.78)×10~9/L, the transform rate of T lymphocytes from (43.0 ±10.0)% to (56.0 8.7)%, plasma ablumin from (22.9±7.4)g/L to (38.0±3.8)g/L, creatinine reduced from (350.0±135.6)μmol/L to (280.5±116.3)nmol/L and β_2 microglobin from (11.34±1.6)μg/ml to (8.1±1.5)μg /ml. The proteinuria became negative after transplantation for sev-eral days.