全取代胍基衍生物的合成及其与核苷酸或丁二酸分子间相互作用研究

Fully Substituted Guanidine Derivatives' Synthesis and the Study of Their Molecular Interaction with Nucleotide and Adipic Acid

通过酰氯作为活性中间体与四甲基胍反应 ,制备出具有不同空间结构的新型胍基化合物 ,其结构经元素分析 ,IR,1H NMR,EI-MS,HRMS等表征 ,并通过 1H NMR初步研究了其中部分化合物与核苷酸及丁二酸的分子间相互作用 。

Five guanidine derivatives bearing acyl group were synthesized by the reaction of acyl chloride with 1,1,3,3-tetramethyl-guanidine. Their structures were confirmed by elementary analysis, IR, 1H NMR, EI-MS and HRMS. Preliminary results of interaction with nucleotides and adipic acid showed that some of them have the abilities of molecular recognition.