表皮生长因子受体与子宫平滑肌瘤的关系

Study on Relationship Between Epidermal Growth Factor Receptor and Uterine Leiomyoma

目的 探讨表皮生长因子受体(EGF-R)与子宫肌瘤的关系。方法 对28例子宫肌瘤标本用免疫组化法测定雌激素受体(ER)、孕激素受体(PR)含量,用流式细胞仪测定EGF-R水平,以正常子宫平滑肌作对照。结果 与对照组相比,肌瘤内ER、PR和EGF-R显著升高(P<0.01);肌瘤内ER、PR含量与EGF-R水平呈正相关。结论 EGF-R在子宫肌瘤的增长中起重要作用,雌、孕激素可能影响肌瘤内EGF-R的表达。

Objective To investigate the relationship between EGF - R and uterine leiomyoma. Methods The ER, PR contents and EGF - R levels were determined by immuno - histochemistry and FCM method in 28 patients with uterine leiomyoma and myometrium (control). Results The ER, PR contents and EGF - R levels in leiomyoma were significantly higher than those in the myometrium ( P < 0.01); There was positive correlation of ER/PR content versus EGF - R level in uterine leiomyoma. Conclusion The EGF -R may play an imptortant role in leiomyoma enlargement; estrogen and progesterone may affect the expression of EGF - R in leiomyoma.