艾司洛尔抑制小儿腭裂修复术中的心动过速

Esmolol in inhibiting children tachycardia in palatoplasty

目的 :观察艾司洛尔 (esmolol)对小儿心动过速的影响。方法 :将 30例先天性腭裂患儿随机分成三组各 10例。A组为对照组未用艾司洛尔处理。B组和C组分别于手术开始时静脉推注艾司洛尔 1mg/kg和 0 .5mg/kg ,记录气管插管前后、手术开始后 1min、5min、10min患儿的心率、血压 ,并进行统计学处理。结果 :A组气管插管后及手术开始后各时间段的心率较插管前显著增快 (P <0 .0 1)。B组和C组手术开始后 1min和 5min心率较A组明显降低 (P <0 .0 5～P <0 .0 1) ,较插管前显著降低 (P <0 .0 1)。 10min时心率接近插管后的心率。B、C组手术开始后 5min收缩压明显低于A组 (P <0 .0 5 )。B、C两组间的心率变化无明显不同 (P >0 .0 5 )。结论 :艾司洛尔抑制小儿腭裂修复术中的心动过速效果确切 。

Objective:To observe the effects of esmolol on children tachycardia.Methods:Thirty children with congenital palatochisis were randomly divided into group A,B and C( n =10),Group A acted as controls.Group B and Group C were injected intravenously 1 mg/kg and 0.5 mg/kg esmolol respectively at the beginning of the operation.Heart rate,blood pressure were recorded before and after endotracheal intubation,and 1,5 and 10 min.after the beginning of the operation.The data were analysed statistically.Results:The heart rate was much faster after endotracheal intubation and after the beginning of the operation than before in group A( P <0.01).The 1 and 5 min.heart rate after the beginning of the operation was obviously lower in group B and C than that in group A( P <0.05 to P <0.01),and the heart rate of 10 min.was near to that immediately after endotracheal intubation.The systolic pressure 5 min.after the beginning of the operation was lower in group B and C than that in group A( P <0.05).The change of heart rate in group B and C was not significantly different( P >0.05).Conclusions:Esmolol is safe and reliable in inhibiting children tachycardia and the effect was definite.